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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Immigrant populations in Arkansas, North Carolina and Tennessee have more than tripled since 1990, noted Lee Drutman, a senior fellow at the New America Foundation, in an analysis for Vox. Anxiety over those changes may explain why the Republican Party became so much more focused on limiting immigration over that period — and why white voters in those states overwhelmingly support Mr. Trump.
First, the companies that gained the most consumer love ...

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

On the sales front, General Motors and Ford F -0.13% lost market share to Chrysler, which leveraged its Jeep brand to previously unimagined heights – and then, metaphorically left its heritage behind when it established legal domicile in the Netherlands and changed its name to FCA US LLC.
英国《泰晤士高等教育》专刊于上周四公布的一项调查显示,中国内地两所高校入选亚洲大学前三名。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

While the real Rain Man never counted cards, his mental abilities were just as unbelievable. Kim Peek was a uniquely talented savant who possessed a nearly perfect memory. Among his many skills, Peek memorized every road on the map, the composers and dates of countless songs, and incredibly detailed historic facts. After Rain Man, he spent his life touring the country and campaigning for the disabled, to the delight of many who were able to witness his unique gift in person.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

这个眼光长远的女孩也希望自己在网络上的知名度能够帮助自己跻身演绎界,为她谋取一个在美国广播公司制作的美剧《童话镇》中饰演艾丽莎一角的试镜机会。该剧将在下一季中加入艾丽莎这个角色。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

"这个家伙对当前情况作了利弊权衡:他有很大机会从故障电梯逃生,但是如果家庭作业没完成,他会很倒霉。"一名名为Zealshifang的用户调侃道。
“Thutmose III was one of the most important pharaohs in Egypt’s New Kingdom and is credited with establishing the Egyptian imperial province in Canaan,” said Gabriel Barkay, the co-founder and director of the Temple Mount Sifting Project.
在《醉乡民谣》(Inside Llewyn Davis)中,编剧兼导演乔尔?科恩(Joel Coen)和伊桑?科恩(Ethan Coen)兄弟俩挥之不去的忧伤情绪转化成了令人难忘的戏剧性场面。我觉得我的评论本应澄清,这部关于流行文化牺牲品的悲歌有一种特别的味道;其中一些部分相当阴郁。奥斯卡?伊萨克(Oscar Isaac)在片中出演一位自暴自弃的民谣乐手,宿命般地献身于他的艺术,他的卓越表演令这部影片极其震撼人心。
医疗、医保、医药联动改革

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

The year’s most compelling makeup and hair designs have been almost characters themselves (and are certainly more dynamic than some of those who appear on-screen). But while physical features are obvious right away, they can also give shape and nuance to the performances of those who assume them. Sometimes, a big nose creates a window of understanding.
这是自从2011年以来谷歌首次荣登榜首。
在上月销量最高的SUV和MPV制造商中,大家所熟悉的长城汽车和上汽通用五菱汽车成功卫冕。在轿车和掀背车型上,上汽大众也保持其冠军地位。
For: The Los Angeles Critics Association gave it their top prize.

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 中高端涂料“军备竞赛”
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Harry Styles, 'Harry Styles'

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 真房源 痛点到底有多痛?
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Sina's Weibo service, for example, has long offered features that Twitter lacks, notably a commenting function that allows multiple users to add their own thoughts to a user's posts. Tencent's QQ instant messaging service, which has more than 700 million users, offers additional features such as skins to change the look of the client and serves as a portal for the company to advertise other products and services. Sina declined to comment.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Good Time
The ranking is based on surveys of schools and alumni who graduated in2011. This edition gives a snapshot of alumni’s situation compared with when they started the programme.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Singapore tops the list as the most expensive city for the third time in a row, but in a year when costs around the world have been highly volatile.
As for the molecular motors, they’re geared up to bring huge potential to the fields of medicine and energy.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 租房“坑”多 小心中招
Open Access Review Article

Diagnostic technologies for COVID-19: a review

It was the spring of hope, it was the winter of despair…
瑞典就人道主义援助贡献基金而言,属于最慷慨的国家之一,整体排名第六。“公民权益”排名第二,“最佳绿色生活国家”排名第一。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

7. Am I working too hard? Taking time to re-charge and spend time on activities that make you happy is so important. Honor your desire to pull back from work or school pressure when needed and give yourself time to breathe, even if it’s only for a few minutes at a time.
杜邦自称“金鹰”,有着独特的,鹰隼般的外形。设计师们想塑造出那个外形,但又不想弄得跟杜邦本人一模一样。
面对批评,梅耶尔4月份接受本刊采访时为自己的决定进行了辩解,她说人们“错误地把这项措施视为行业条例。”她表示,自己需要员工在办公室工作,目的是鼓励他们进行合作与创新。目前看来,这个不同寻常的做法可能正在对雅虎产生积极影响——2012年梅耶尔上任以来,这家公司的股价已经上涨了一倍多。
At age 20, the teen prodigy of "Royals" raised the bar, marrying the massive vistas of electronic music alongside the human-scaled and handmade on her second LP, with help from co-producer Jack Antonoff.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

好市多首席执行官克雷格杰利内克

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

adj. 人口统计学的
该书反映了部分群体越来越担忧自动化可能对就业——从制造业到专业服务领域的就业——产生的负面影响。该书英国版的副标题警告了“大规模失业的威胁”,美国版的副标题则预言了“一个失业的未来”。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Kellogg/HKUST dominated this ranking from 2009 to 2014 but lost out to Trium in 2014 and to Tsinghua University/Insead in 2015.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

所以,是的,我认为他们应该果断垫底甚至交易伊巴卡以换取更多的价值,尽管这变脸来得有点快。唉,天啊,这支队伍实在太诡异了。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

n. 日历,月历,日程表
We will ensure that foreign trade continues to pick up and register steady growth.
"She gave her surname as Han when registering, which is also different from the name Su in media reports," the employee said.
狼和狗有何不同?

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

随着经济增长放缓,中国政策制定者对银行放贷速度越来越担心。中国银行业监管机构的数据显示,去年中国银行业资产规模增加了逾72万亿元人民币(合11万亿美元)。
Lighting is key when it comes to getting work done. Instead of investing in your typical, boring college dorm room desk lamp, pick something with a prettier design. Check out vintage stores for one-of-a-kind table lamps or keep it cheap with the Tiffany Table Lamp, $99.99, at Target.com.
大宗农产品投机交易一直是今年市场波动的一个特点,荷兰合作银行预测,这种趋势将继续。
就业增长超出预期;
单词conservative 联想记忆:

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 中东LED照明灯具市场蓬勃发展
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

American brands such as Chipotle, Texas Instruments and General Dynamics are on the list for the first time.
该报告调研了156个国家,结果显示,丹麦、挪威、瑞士、荷兰和瑞典是幸福指数最高的前5个国家。而撒哈拉以南非洲的大部分国家——卢旺达,布隆迪,中非共和国,贝宁和多哥等则被该报告评为幸福指数最低的几个国家。中国列第93位。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

We will boost the development of modern agriculture.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

2016的很多电影都会有很好的票房号召力,但人们迫不及待想要观看的其实只有那么几部。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

But that moment, try as Google might, has yet to come. Some reports have named 2014 as the year when wearable devices will hit the mainstream, but a newer study from L2, a digital research firm, confirms what many have been quietly fighting for: wearables are still not socially acceptable, creating a significant hurdle to further sales.
会。莫迪一夜之间废除大面额纸币的做法令人震惊,严重扰乱了印度经济。但此举带来了丰厚的政治回报,支撑了莫迪作为愿意采取严厉措施打击腐败的果决领导人的形象。面临2019年的下一届大选,莫迪很有可能想拿出另一项轰动性措施来博取选民的支持。当心,他可能会对那些为了隐藏资产而以他人名义持有房产的富人采取重大行动。
But the change in Wall Street’s — and Silicon Valley’s — appreciation of Mr Cook is down to more than just the 70m iPhones Apple is expected to sell this quarter or the $42bn in sales generated in the previous.
The end of November is here. As I wrote Monday, recent history suggests nine teams have pretty much already been knocked out of playoff contention. Yet, none of them are straight-up tanking.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

艾伦·狄珍妮丝:
国家大学排行榜单数量从去年的38份上升到42份。新加入的榜单包括阿根廷、墨西哥、巴基斯坦和罗马尼亚大学排行榜。
Magic show (Lu Chen)
['?kjurit]

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 日系家电告别中国倒计时
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

“气候变化也许是我们这代人的重大挑战,”美国国家航空航天局(NASA)地球科学部主任迈克尔·H·弗莱利赫(Michael H. Freilich)说,他的部门是跟踪全球气温的机构之一。
A recent example: When Gwen Stefani launched her new album Spark the Fire, Swyft created a free sticker pack and distributed it on several of its messaging apps. It was downloaded almost a million times and sent between users seven million times, resulting in 41 million impressions in 10 days. Such campaigns cost anywhere from $50,000 to $250,000 for brands, Wray says.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

全球性肥胖
With the prices of most commodities having recovered somewhat since February 2016, the year-on-year fall in unit prices has slowed to around 5 per cent.
8. 《疯狂的麦克斯4:狂暴之路》,导演:乔治·米勒。
The emissions growth last year was a bit slower than the average growth rate of 2.5 percent over the past decade, and much of the dip was caused by an economic slowdown in China, which is the world's single largest source of emissions. It may take an additional year or two to know if China has turned a corner toward slower emissions growth, or if the runaway pace of recent years will resume.
单词facilitate 联想记忆:

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Quite a few students were disillusioned by UK visa regulations. “A lot of people saw the programme as a gateway to employment in Europe,” says one. “If this was the objective, then a lot of them would have gone away unfulfilled.”
Chinese manufacturers:Coming to the U.S.? Warren Buffett’s BYD says it is arriving in 2015 and Geely in 2016 but we’ve been hearing that someone was coming since at 2006. The refinement of Chinese cars is the issue. With more than 80 local automakers producing 524 different models in China, R&D money is spread too thinly to produce meaningful results.
v. 使防备,支撑,拉紧,使绷紧

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

时间:2010-03-31 编辑:vicki
If 2017 was the year of fake news, 2018 is shaping up to be one of fake data. And just as fake news comes in many varieties — real news dubbed by the US president as fake, as well as nonsense gaining huge audiences on social media — so does fake data.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

特斯拉(Tesla)正处在蜜运中。这家电动汽车公司的财富以不可思议的速度积聚,而投资者仍在热烈地追捧它。
"As a native of Shaanxi, I found Sun played the role well. She jumps and runs wildly, just like a typical young naughty Shaanxi girl," a netizen Xuelili said.
A robust LinkedIn presence is crucial to any job search. You know that. Your manager knows that. And your manager probably knows that you know that – so she'll be concerned when you go from having a bare-bones profile on Monday to one jacked with additional work history, new connections, status updates and recommendations by Friday. "Don't go from zero to 500 overnight, because that can be quite obvious," Foss cautions。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Yet expectations for the summit meeting on Tuesday are low, with no sign of any political breakthrough that would lead to more ambitious efforts. Scientists say emissions must peak within the next few years, and then begin to decline, if the world is to have any hope of keeping global warming to an upper limit that countries agreed on five years ago. So far, no plans are in place that would come close to achieving that.
Information technology was the third largest sector with 18 brands shortlisted. The total value of listed IT brands accounted for 22.5 percent of the list. Average value increased 10 percent. Beijing is the preferred headquarters location for the IT sector, and 12 listed IT brands set their headquarters there.
今年最引人注目的化妆和发型设计几乎都源自角色的原型本身(其中有些无疑比银幕上的造型更有活力)。除了能让观众一眼看出角色的外貌特征,它们也能为演员的表演赋予整体感觉和微妙之感。有时,一个大鼻子就能加深观众的理解。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 深圳超八成租客租金收入比不到30%
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

China’s trade with the rest of the world fell sharply in October from a year earlier, with imports of raw materials particularly hard hit as slowing Chinese investment feeds through into weaker demand in the world’s biggest trader of goods.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Mayweather vs McGregor Fight

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

The OJ Simpson trial proved that nothing gets the masses as excited as murder and celebrity. Throw in Flight 253 and the ambitions of dozens of terrorists, trial lawyers, prosecutors, politicians and aggrieved 9-11 families and you have a story that will run and run.
她声名在外,母亲不得不为她雇了专人保镖团队,全天24小时保护她的安全。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

['treidmɑ:k]
据悉,这个女孩来自上海,在两个月间每天都通过她妈妈的手机和银行卡,给这名男子网上支付1900元到9500元不等。
数百名为爱痴迷的爱尔兰球迷在球场外集体围着并示爱法国金发女郎。一名仰慕者最后甚至索吻成功。
9.We here in the UK want nothing more than to provide you, our guests, with a fantastic experience this summer, combining the best in international sport, brilliant facilities, fantastic entertainment and a cultural legacy that draws on centuries of excellence in art and architecture. If you ended up with four tickets for the wrestling at the ExCel Centre, well, better luck next time.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

不过,时间不等人,特朗普总统也正通过威胁退出谈判而极力增添一些戏剧性的紧张感。
纸筒插秧机可以让一名使用者在几分钟内在85英尺(约合26米)长的一块田地里种植264棵幼苗。这在以前通常耗时数小时,如今只需几分钟。使用者在种植农作物上花费的时间更少,可以节省出更多的时间做其他的事,比如农田改进、市场销售、或者干脆休息休息。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

就目前而言,虽然偶尔出现一些高价交易(比如大新金融中心、以21亿港元售出的太平山顶豪宅),但整个行业弥漫着广泛的悲观情绪。世邦魏理仕数据显示,今年第一季度房地产业最活跃的部分是写字楼,但交易总量也不过8笔。
"某时,世界呈现给我们是相互分隔的,但是这些电影和电视作品让我们感觉世界是相通的,"美国电影学院的总裁兼首席执行官Bob Gazzale如是说。"美国电影学院奖表彰这些电影艺术家们,勇于挑战,让我们受到鼓舞,娱乐,又励志,最后让我们意识到,我们都有着同样的心跳,"

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

[ri'sp?ns]

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

停战日在1938年成为美国的正式节日,但在1954年改称退伍军人节。当时是第二次世界大战和朝鲜战争结束不久。退伍军人节跟每年五月最后一个星期一的阵亡将士纪念日不同。
? Ten of a reported 33 fatalities occured in New York City, and that number was expected to rise, according to Mayor Michael Bloomberg. Deaths in New York were attributed to falling trees, electrocution and drowning.
单词pressure 联想记忆:
All employees receive a $25 monthly credit to the DreamWorks PrintCenters at the Glendale and Redwood City campuses. Charged only for supplies, the studio is able to offer inexpensive services that range from printing photographs to creating greeting cards and personalized calendars.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

200亿美元的数额会让任何一位投资垂涎,但这笔钱需要在回购和派息之间进行分配。与2014年其他公司宣布的股票回购相比,这笔钱只能算是零花钱。
Spotify, the music streaming service, plans to list existing private shares directly on the New York Stock Exchange as soon as the fourth quarter rather than doing a formal IPO, while other large, well-known tech companies for now were seen as more likely prospects for 2018, bankers said.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

headway
如果陆金所成功完成此轮融资,将可凸显出该行业今年以来增长有多快。该公司刚在4月融资5亿美元,公司估值在当时达到100亿美元。
Stand: Yahoo CEO Marissa Mayer defended work-from-home ban

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

这是今年最精致的浪漫电影与最尖锐的反浪漫电影,均来自美国电影界最缜密的聪明人。两部影片之间的关系最好用一首威廉·布莱克(William Blake)的诗歌来总结——《土块与卵石》(The Clod and the Pebble)。
Enthusiastic supporters of the idea of a “universal basic income” for all citizens, meanwhile, will look to Finland where a trial is now well under way. In France, Emmanuel Macron will try to tread a delicate line in 2018 as he reforms the labour market, hoping to inject flexibility without increasing insecurity or incensing the unions.
"The Chinese government, universities and investors have provided a friendly environment for young startups. However, the failure rate of fresh graduates founding startups is still too high due to the lack of experience, resources and networking," said Wang Yixin, a senior consultant at Zhaopin.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

A thin line separates confidence and delusion, and Kobe Bryant is straddling it. It's the only conclusion one could reach after judging the Los Angeles Lakers star's comments Tuesday after he tied the worst shooting performance of his career in any game in which he attempted at least five shots.
1. Buy expensive tailored clothing that only sort of fits so that most of the time your buttons appear to be just seconds from bursting.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

The prospect of a major shakeup right before the deadline is usually a recipe for disaster, especially if it leads to immediate roster change.
When I am creating a light novel, Iam creating it mostly alone. When I am working on anime there is a director andthe staff with a point of view on my works. There usually are several revisionsregarding the storyboard. What is interesting is what will come back. It's avery interesting part of the work.
以下是五个脱颖而出的、值得在2014年加以关注的初创企业。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Temperatures in 2015 also shattered the previous record set in 2014 by 0.13C, according to Nasa.
Brazil

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 顺德人才租赁房:免租或半价租
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

['minits]
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。
?在纽约的交通基础设施遭受巨大的打击。许多城市的地铁隧道被淹没。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Inarritu said: "I forgot to thank all the native Americans who made this film possible. I cannot say how surprised I am and how proud I am to have survived this film with all these fellows."

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

长久以来,科学家一直在研究干细胞分化为心脏组织的潜力,今年当他们创造出可以自己搏动的心脏组织时,这一研究工作达到了一个重要的里程碑。
哥伦比亚美女夏奇拉集歌手、作词人、舞蹈演员、唱片制作人、舞蹈编剧以及模特于一身,她在2015全球美女榜中位列第十位。她还曾登上福布斯全球权势女性榜,以及“舞动奇迹”最受欢迎舞者榜。2014年7月,她成为脸书粉丝过亿第一人。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

发展文化事业和文化产业。
英国和法国成为欧洲商学院教育的两大来源。在上榜商学院中,近一半要么来自英国(20所),要么来自法国(19所)。从排名、毕业生薪资(法国为5.5万美元,英国为4.9万美元)以及学生数量(法国为9000人,英国为1200人)看,法国在管理硕士课程方面强于英国。然而,从MBA商学院数量(英国上榜商学院为18所,法国为5所)和学生数量(英国为1900人,法国为1300人)来看,英国商学院MBA课程强于法国,尽管在毕业生薪资方面,英国MBA课程(11.5万美元)不敌法国(13.7万美元)。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 北京“官批”28日19时正式闭市
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

韩国最大的整形医院之一,由权株创立的JK整形手术中心,近期开了一家旅馆来更好地服务顾客。这些顾客每次看病人均花费17675美元。
And despite exports having fallen 7.3 per cent during the same period.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 朗诗加速布局美国市场
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

尽管购汇限制并未调整,但监管部门现在要求个人详细披露到底要用购得的外汇去做什么。购得的外汇只能用于旅游和购物、留学、境外求医以及咨询服务等经常项目支出。房地产和其他投资性支出属明确禁止之列。
预计将有8900多万企业退休人员和1700多万机关事业单位退休人员从中受益。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 上海8人摇号456套房
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

这是智慧的时代,也是愚蠢的时代……

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 保定17宗地块挂牌出让
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

That Teach First was able to overcome such conditioning is testament to the power of a scheme that has become both a rival to UK private sector recruiters and a finishing school for them.
[?'naunst]
2002年,一名4岁的小男孩患有耳聋,但他不愿意戴助听器,因为超级英雄们都不戴。之后,漫威(Marvel)创作了一个戴着助听器的蓝耳侠(Blue Ear)。
从校友达到目标的程度来说,伦敦商学院课程的排名一直领先。一位2010届MBA毕业生在回应英国《金融时报》的调查时表示:“凭借我找到的工作,我不仅实现了自己设定的目标,还超出了这些目标。”

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

A total of 3,077 new cases of HIV infection took place in colleges and universities across China in 2017, according to the National Health Commission (NHC) at a press conference on Friday.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

9. Smiling
[nju:'tris]
《少女日记》,导演玛丽尔·海勒。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

[sp?n'teini?s]
10. Run the Jewels “Run the Jewels 2” (Mass Appeal) Speaking of urgent and stinging, Killer Mike and El-P, veteran underground rappers from different scenes, found firm traction on their second round as Run the Jewels. Their flow is strong and their focus is furious on an album that calls out power structures but lets nobody off the hook.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

维多利亚的秘密内衣秀刚刚拉开华丽巨幕,今年的秀也是有史以来最奢华复杂的一次。
9.亲爱的贵客们,我们希望英国能为你们贡献一个美好的夏天,这个夏天包括了顶尖的国际赛事、先进的设施、有趣的娱乐、以及汇集了几个世纪的艺术建筑精华的文化遗产。如果你最终只收获了四张卓著国际中心的摔跤比赛门票,好吧,祝你下次好运。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 微电影营销 品牌你投对了吗?
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

“Today you have to shop by image,” Mr. Nathan said. “But if you are brave and don’t follow fashion, there are opportunities.”

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 南京退房量小幅攀升
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

……太紧张,差点昏过去。
Justin Bieber's split from Selena Gomez was the most enquired-about relationship bust-up while Victoria Pendleton beat Georgia Salpa as the most searched-for participant in a reality television show.
It was not an auspicious start to the new year for bitcoin investors.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

“Even if you have made your peace with a Fed rate rise there are other reasons to be nervous,” said David Hauner, head of emerging markets at Bank of America Merrill Lynch, who points to falling oil prices and the slowdown in China to illustrate why market volatility measured by the CBOE’s Vix index, a barometer of investor sentiment, has been elevated since August.
里奥斯工作非常努力。她很小的时候就从萨尔瓦多来到了美国。以优异成绩从高中毕业后,她一边养家,一边读完大学。成立Nation Waste Inc.公司的时候,她并没有感到害怕。22岁的时候,里奥斯刚刚从休斯敦大学(the University of Houston)毕业几个月就贷款购买了两辆卡车,毅然投身由男性主导的垃圾处理行业。目前,这家位于休斯敦的公司有24名全职员工。里奥斯说:“回头看看过去的经历,总是让我感到吃惊。我很小的时候就跟着父母来到美国,现在我正在实现我的美国梦。”
科学家表示,全球变暖加上强大的厄尔尼诺气候事件,令2015年成为自19世纪现代记录开始以来最热年份。科学家还警告,今年地球可能会更热。
n. 社交聚会

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 三安打响2017LED涨价“第一枪”
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

以下是五个脱颖而出的、值得在2014年加以关注的初创企业。
[k?'m?:l]

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

第十步 如果以上几条都做不到——就公告天下说你有反社会人格
海莉·威廉姆斯依然是颇有影响力的重要存在,一位不论是低声哼唱还是大声呐喊都能令人信服的歌手。她直言不讳的勇气几乎使你忘记《欢笑过后》记录的是她对这个世界的厌倦。
有A型人格特征的人往往是高成就的“工作狂”。他们用最后期限激励自己,讨厌延迟和矛盾心理。A型人格的人工作压力更大,工作满意度更低。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

项目长度:22个月
No one since Michael Haneke has enjoyed cinematically dissecting social conventions as much as Greek film-maker Yorgos Lanthimos. His The Lobster took Cannes by storm two years ago with its scathing look at a society that turns adults into animals if they cannot find a romantic partner within 45 days – it was our world but pushed toward the outermost limits of groupthink and conformity. Now he’s back with The Killing of a Sacred Deer, a domestic thriller about a surgeon (Colin Farrell) and his wife (Nicole Kidman), also a doctor, who befriends a fatherless teen named Martin. The boy seems determined to expose the family’s secrets and unmask a terrible trauma from their past. Is this film about how domestic (and perhaps societal) tranquility sometimes depends on shared, agreed-upon lies? Either way, prepare to be unnerved. Released November 9 in Denmark, November 16 in Russia and November 30 in China's Hong Kong. (Credit: A24)

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