HTTP/1.1 200 OK Cache-Control: no-cache, private Content-Type: text/html; charset=UTF-8 Date: Mon, 23 Nov 2020 21:23:01 GMT 深夜直播app
Jump to main content
Jump to site search

Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

供给侧结构性改革初见成效;
A型与B型人格理论指出,A型人格的人外向、野心勃勃、严谨、地位意识强、敏感、不耐烦、焦虑、积极主动和注重时间管理。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

有些人则特地请人代劳:
The most popular surgical procedures include double eyelid surgery - which reduces excess skin in the upper eyelid to make the eyes appear bigger, lipoplasty - which uses high-frequency sound waves to eliminate fat - and nose jobs.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

立场:提倡“自觉资本主义”

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

7.《风流医生俏护士》主演未与剧组签合同

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

The pipelines were building in spite of poor performance for this year’s high-profile deal from Snap, the owner of Snapchat, in the US and investor concerns that a strengthening euro may curtail the earnings recovery in Europe.
['regju.leit,'regjuleit]
白人焦虑推动了今年的西方政治动荡:英国令人震惊地投票决定退出欧盟,美国的唐纳德?J?特朗普(Donald J. Trump)出人意料地获得了共和党的总统提名,挪威、匈牙利、奥地利和希腊的右翼民族主义崛起。
要实现有效的电子邮件营销,可不只是偶尔发一封电子文宣邮件那么简单。要想构建一套有效的电子邮件营销战略,你需要一个功能齐全的工具。MailChimp似乎是市面上最佳的此类系统,它提供了各种典雅直观的电邮广告模板、先进的分段功能和营销自动化功能。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

但是更让人兴奋的是,魔术师约翰逊是一个人脉广泛且备受尊敬的名人堂球员,他看起来也能知人善任,新经理罗布-佩林卡是一个老谋深算的交易者,他在联盟人脉也很广。
好市多首席执行官克雷格杰利内克
9.Use One Planner
拉斯维加斯枪击案

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Among the major U.S. airlines, US Airways had the best holiday on-time performance, coming in fifth with 15.57 percent of its flights arriving late during Thanksgiving and Christmas. Meanwhile, American Airlines, with which US Airways plans to merge, was the fourth worst, with 19.7 percent of flights arriving late, according to FlightAware.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 购房者积极入市 开发商不敢涨价
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Net interest margins — the difference between interest paid on deposits and interest gained from loans — suffered as China lifted its remaining controls on the interest rates paid on deposits. The average margin declined by about 46 basis points to 2.54 per cent in 2015.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 执行程序中 如何保护承租人权利
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Man got to sit and wonder ‘why, why, why?’
In 55th place, University of Edinburgh Business School regains the rank it held two years ago. The school dropped down the tables last year after failing to make it into the Masters in Management ranking. The University of Bradford School of Management recorded its best progression, aided by the school’s first appearance in the ranking of the top 100 Executive MBAs.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.
Another love ballad for Bond, but if Nancy Sinatra's song from You Only Live Twice was playing at your orthodontist's office, it would be the sexiest orthodontist's office in town. There's a mysterious quality to the string section, and a playfulness to the declining notes. They combine to make something rather magical. From here on out all of the Bond songs on this list are bona fide classics.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 家具以旧换新中标企业名单揭晓
Open Access Review Article

Diagnostic technologies for COVID-19: a review

在欧洲所有商学院中,高管MBA校友在毕业3年后的平均薪资为14.3万美元,管理硕士毕业生为5.4万美元。MBA毕业生平均薪资为12.3万美元。西班牙和德国的管理硕士毕业生在毕业3年后的薪资最高,均为平均7万美元。法国MBA毕业生和瑞士EMBA毕业生的薪资最高,平均薪资分别为13.7万美元和16.6万美元。
2.Jennifer Lopez

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

200911/90348.shtmlHere are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!
Feud: Bette and Joan
During the summers, Good Humor ice cream trucks visit the company's campuses every other Friday during lunchtime. In the fall, cider and doughnuts are served twice a month, mid-morning.
Form without content. Which is why devolving to such familiar forms seems like a safe bet, and why it really isn’t. It’s empty and disposable — which is in turn why the 1960s keep being identified as a “trend,” with the associated implication that at some point they will also be identified as “over.” Even though that “over” has yet to come.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

adj. 自信的,有信心的,有把握的

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Song “Family”(Tan Jing)
[grɑ:nt]

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Wang, the chairman of Dalian Wanda Group, took the top spot with a personal fortune of $32.1 billion, the report said, despite Ma seeing his wealth surge 41 percent from 2015.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 平心而论 城市改造应溯本求源
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

vi

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

That Apple could launch a 2,000 yuan ($330) iPhone mini and be competitive with flagship products from Lenovo, Huawei, ZTE and Coolpad.
一只五人帅哥音乐剧组合Callabro赢得了大众的青睐,赢得了最高选票,成功卫冕。与此同时,他们还获得了250,000英镑的现金奖励,还获得一次在皇家面前表演的机会。
2. Do I have too much clutter? Drowning ourselves in too many material possessions can ultimately lead to stress. Get clear on what you absolutely need and what you can get rid of.
以下四个因素应该会对2013年的就业复苏起到推动作用:[qh]

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

May you have the best New Year ever.
Song “Embrace Happiness”(Kelly Chen)
1. Discipline them: Of course disciplining our children is a given in any home. But we need to ask ourselves if we are disciplining our children properly? Who
Heavy air pollution from Beijing, which saw its worst bout of smog in recent history in January, to Shanghai, where pollution levels went off the charts in December, certainly don't do much to help attract tourists.
Beijing Capital International Airport performed slightly better, with its punctuality rate reaching 60.7%.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 中心城区绿色出行比例去年达72%
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

[p?n'demik]
[f]

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

There's plenty more to figure out in the coming months, plenty more to speculate about, plenty more to enjoy. Here's wishing all of our readers a safe and enjoyable holiday season, and a happy new basketball year.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

国际移民组织说,2015年进入欧洲的移民和难民数量已超过一百万,为二战结束以来最大的移民潮。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 微电影逆袭陶卫行业
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

trans转移+port拿,运→移动着拿→运输
加拿大整体排名第二,幅员辽阔,位居世界第二。“生活质量”与“教育最佳国家”均居首位。
部分在企业界的资助下,该机构将一流毕业生派到面向低收入社区的学校至少两年时间,而且也完全知道,其中许多人将会在这一时期结束后不再从事教学工作。
adj. 浓缩的;扼要的 vt. 浓缩(condense

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

联邦控制委员会要求修订的财政计划必须在1月底前批准,举出加西亚去年提交的部份是不现实的,并过度依赖联邦资金。加西亚拒绝提交一项修订计划,包括紧缩措施。罗塞略已经表示,他将要求延长还款期限与在2月到期的延缓偿付,目前保护波多黎各避免被愤怒的债权人诉讼。
有理由怀疑纳伦斯-诺埃尔是否能成长为可靠的先发中锋,这些理由包括他的伤病史、场外红灯行为和非常有限的进攻手段。
“Why do we keep getting so many record-warm years?” Dr. Schmidt asked in an interview. “It’s because the planet is warming. The basic issue is the long-term trend, and it is not going away.”
['minits]

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

This was never more powerful than when he talked publicly for the first time about his sexuality.
Other engines cited among 2014’s best include turbodiesels in the BMW 5 Series luxury sedan and the compact Chevrolet Cruze, the horizontally opposed 2.7-liter six-cylinder in the Porsche Cayman two-seat sports coupe and the 1.8-liter turbo-four in the compact Volkswagen Jetta sedan.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

在这个力求避免任何歧视的态度的年代,年轻一代开始不满邦德的大男子主义态度和不健康的生活方式,因此赫洛维兹引入了一系列会指出邦德错误的新人物。
Committee Chairman Thorbjoern Jagland praised the work of the three recipients, saying that "we cannot achieve lasting peace in the world unless women obtain the same opportunities as men."
几家与韩国有关系的机构已经感受到了北京方面对萨德计划的怒火。上个月,由于乐天(Lotte)出让土地用于部署萨德平台,中国官方新闻机构新华社(Xinhua)向乐天发出了强硬警告。乐天是韩国最大的企业之一。
“It suggests that people put more weight on what happened to themselves and less weight on other information that might be available,”Koudijs says. The more personally removed people are from an important event, the less it is to affect their appetite for risk.
10. Mail carrier

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

当然,这些新势力也可能引发反弹,使得指挥-控制的老派领导方式卷土重来。令人郁闷的是,主宰世界舞台的政治人物大多是老派的,而他们面临的领导力挑战——从英国退欧到朝鲜问题——尤为复杂。
此外,维密的许多其他模特也被禁止入境,包括来自俄罗斯的朱莉亚·贝亚科娃、凯特·格里戈瑞瓦和伊丽娜·莱巴里科娃以及乌克兰的达莎·凯尔斯顿。
A powerful earthquake struck off Japan's southern coast on May 30, prompting fears in China of a catastrophe similar to the tsunami and Fukushima nuclear power plant meltdown that followed the 2011 Japanese quake. In the end, no fatalities or major damage were reported.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

China's mass entrepreneurship and innovation initiative has a strong vitality.
答:AZ里面的角色不是我创作的。在最初版本出来之前,我给故事写了大纲。但伊奈帆这个角色最后呈现出来的,其实和我写的不大一样。我和这个角色之间没什么联系,所以说这个人物算是例外吧。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

It plans to help at least 130,000 rural people cast off poverty and relocate 163,000 residents in 2017.
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
赫洛维兹承认,他这样做时不得不小心翼翼,以保存这部间谍小说的首位作者伊恩·弗莱明(Ian Fleming)所创造的007的个性和态度。弗莱明于1964年逝世。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Insecure
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
同样,A型与B型人格理论指出,B型人与A型人截然相反。根据定义,B型人格的人生活压力较小。尽管他们在没有实现自己的目标时更容易忽视身体或精神上的压力,但通常可以稳定工作,享受成功。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 新就业无房职工公租房再推1540套
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Meanwhile the services PMI reading for the month was 51.2. It had been 52 in October. The manufacturing PMI, reported earlier this week, came in at 48.6 in November, versus expectations of 48.3. It had been 48.3 in October

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

According to the report, people living in first-tier cities such as Beijing, Shanghai, Guangzhou and Shenzhen suffer much higher economic pressure, while fourth-tier and smaller cities offer fewer job opportunities and connection plays an important role in every aspect of life there.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Shares in Hyundai and AmorePacific slid on Friday, down 4.4 per cent and 12.5 per cent respectively in late afternoon trading in Seoul.
We will promote the liberalization and facilitation of international trade and investment.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

但现实远比他想象的艰难。雷文斯克罗夫特表示:“我曾以为这就是一个机会,要花掉两年,但现实是严峻的,因为这活不好干。”此外,他的导师在雷曼兄弟(Lehman Brothers)工作,这家银行于2008年破产。他大笑着说:“这段指导关系持续的时间没有我希望的那么长。”
Faster growth should also dispel worries about another Fed bogeyman: deflation, or falling prices. "It's impossible to have deflation in an economy growing 3%-plus and adding the most jobs since the 1990s," Baumohl said.
When things do go wrong, Mr Cook takes swift and merciless action. In late 2012, after the premature launch of Apple’s flawed Maps app, he dismissed Scott Forstall, who led the creation of iOS and was a close ally of Jobs, and John Browett, the former Dixons chief who had led Apple retail for less than a year. The actions sent a message that Mr Cook will not tolerate underperformance or internal politics.
If successful, the funding would underline the rapid growth of the sector this year. In April, Lufax raised $500m at a $10bn valuation.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 增值税改革,全年减税超万亿元
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

On Aug 21, the country came to a pause as millions of Americans — even the president — put on eclipse glasses and stopped to take in the first eclipse to cross the United States since 1918. Its path across the United States was a scientific bonanza for astronomers who were able to more easily point advanced equipment at the sun.
自从2010年开通运营以来,12306票务系统已多次升级以修复漏洞,并在春运期间提供更好的服务。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 从经济数据看民生获得感
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

最近两年你都没有涨薪水
4) I often feel inhibited in social interactions 0 1 2 3 4

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Hurun estimates that there are now 594 US dollar billionaires in China and another 94 in Hong Kong, Taiwan and Macau, compared with 535 in the US.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

3. The root cause of eczema has finally been identified. Scientists have tracked down a series of proteins and molecular pathways that lead to this insufferable skin problem, revealing that the protein filaggrin isn't the sole culprit we thought it was.
生活的起起落落
['?up?nnis]
9、邦德经历风险无数却总能死里逃生。当然,人物本身是虚构的。有意思的是,研究证明,肌肉男更皮实。实际上,肌肉不发达对男性来说,可能很要命。(可能就是发达的肌肉让他得以活命的吧,我怀疑他会死于心脏病或前列腺癌)。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Summly and Yahoo refused to comment on the deal’s terms.
Wang Chunfa, executive secretary of the China Association for Science and Technology, has expressed deep concern over the retraction, which came just days after he met in Beijing with Arnout Jacobs, the head of Springer Nature for Greater China.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

影片讲述了一个神秘的水生生物和莎莉霍金斯扮演的哑女之间超凡脱俗的爱情故事。
For those outside the scientific community, the response to the retraction has been mixed.
3.9 全面加强政府自身建设

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

vt. 切成薄片,削
《不可思议的杰西卡?詹姆斯》
例如比利时,它的人口不到小组赛对手俄罗斯的1/10,但被认为是一个巨大的威胁。而乌拉圭尽管人口还不到400万——仅仅是大圣保罗人口的1/6——却是巴西在通往决赛之路上最不想碰到的球队之一。为何如此呢?

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 木林森将继续加大LED领域投入
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

*Guest Actor in a Drama Series: Hank Azaria, “Ray Donovan”
Yp-V]1tK*%w-SI%Uzt!USrR-s|8#ab-AFvX-TD[

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

The report ranks brands based on financial performance, its influence on customers, and its power to command a premium price or drive company sales.
对中国最大房地产开发商发起敌意收购的神秘亿万富翁姚振华已成为中国最富有的人之一,这凸显出了杠杆金融投资正如何推动私人财富取得巨大增长。
佐治亚州萨凡纳市(SAVANNAH, GA.)

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

这间增加的厨房大约40英尺长(约12米),风格与原建筑保持一致,内有复杂的天花板木制结构和几处由世纪工作室(Century Studios)设计的彩色玻璃板,该工作室是明尼阿波利斯市的一家公司,其玻璃确保来自弗兰克·劳埃德·赖特(Frank Lloyd Wright)曾指定的那家芝加哥制造商。厨房里的不锈钢电器包括一台五英尺宽(约1.5米)的炉灶和一台Sub-zero的冰箱。餐厅区经由10英尺高(约3米)的玻璃门通往屋后的一处露台。
于上周二发布的《2016胡润IT富豪榜》显示,排在前50名的中国IT富豪的平均财富同比上涨13%,至创纪录的269亿元。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

channel
如果你想把内容写作工作的一部分或全部外包出去,那么你首先要确保你获得的内容是原创的。你可以把内容粘贴到CopyScape的分析工具,然后就能立刻知道这些内容是否为原创。
The year’s most compelling makeup and hair designs have been almost characters themselves (and are certainly more dynamic than some of those who appear on-screen). But while physical features are obvious right away, they can also give shape and nuance to the performances of those who assume them. Sometimes, a big nose creates a window of understanding.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Stand: Costco CEO Craig Jelinek refused to open on Thanksgiving Day

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

曲道奎表示:“随着机器人正逐渐扩至几乎所有领域,我国机器人制造商应当了解自身和外资品牌间的差距,利用中国机器人的蓬勃发展并学习国外经验,以帮助我国由世界最大的机器人市场成长为机器人制造强国。”
[.beni'fil]

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

请接受我们对你及你全家的美好祝福,祝你们新年快乐。
8.文盲

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 听说“共享风”已吹到了家居界?
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

这个领域的创新速度非常快。自从Fitbit于2008年成立以来,各家公司已经发布了五到六个完全不同的产品。三星(Samsung)则在九个月内发布了可穿戴设备Galaxy Gear的三到四个衍生产品。索尼(Sony)、Pebble、谷歌和Facebook的头戴式虚拟现实设备Oculus Rift也紧随其后。
World Health Organisation declared that the cluster of microcephaly cases and other neurological disorders were a public health emergency of international concern, it was a rallying cry for the international community to respond.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

下面就是今年汽车业所经历的高峰和低谷:
在这个力求避免任何歧视的态度的年代,年轻一代开始不满邦德的大男子主义态度和不健康的生活方式,因此赫洛维兹引入了一系列会指出邦德错误的新人物。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 日系家电告别中国倒计时
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

此前,跨国房地产经纪机构仲量联行(JLL)的数据显示,2016年全年,中国对外房地产投资额增长了53%,达到创纪录的330亿美元。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 8月卫浴洁具电商市场不温不火
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

8. Flats are allowed on the red carpet – or are they?
赢家:湖人
But when you think of fields where there just aren't enough skilled candidates to go around, one that probably doesn't come to mind is supply chain management: The complicated, behind-the-scenes work of getting goods from one place to another, on time and on budget.
谎言8:我写了5页的简历,那是因为我足够好。说谎原因:我就是个不折不扣的话唠!

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Yet, the disparity in haircuts lasted for almost two years. In fact, the pessimism and risk-aversion of the Seppenwolde lenders reduced the overall availability of leverage in Amsterdam.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

清华大学的毕业生以毕业五年后平均月薪14822元高居榜首。39所高校生跻身万元户行列。此外,共有185所高校的毕业生平均月薪突破8000元大关,789所高校的平均月薪突破了6000元大关。
Meditate any time, but 15 minutes before you study, 15 minutes before class, 15 minutes before a test, and you'll be amazed at how well you can perform as a student.
节目31 京剧《迎来春色换人间》,于魁智 托马斯(孔子学院学员)

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

不过,对韩国和东盟(Asean)国家的出口都下滑了约3%,而对香港的转口贸易下滑幅度逾16%。
In month-on-month terms prices rose only 0.6 per cent nationwide, the first time growth fell below one percentage point in three months and well down from a peak of 2.1 per cent in September.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

此外,今年有66位40岁以下的富豪入选,创下了该榜单的记录,诺依曼,希伯尔曼和夏普三人位列其中。
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

现年22岁的劳伦斯是《饥饿游戏》电影系列的女主角,她还可能凭借在电影《乌云背后的幸福线》中的表现获得奥斯卡提名。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

“我们会根据天气谨慎考虑投送的时间和地点,但这些都不会公开,”脱北者Park Sang-Hak说道,他曾经领导过一系列的气球投送运动。
8. Trang Islands, Thailand-The islands of Trang, a sleepy province in southeast Thailand, have remained under the radar. Wooden longtail boats can be rented to travel between the islands—and to see the endangered dugongs.
伊法斯夫拉腾以英国独立党(U.K. Independence Party)为例,它的官方平台力主脱欧,但是面向选民的宣传中又强调移民对经济与文化的影响,她说这是一种混合了务实与民粹的论调。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

据报道,香奈儿艺术总监卡尔·拉格菲尔德于巴黎去世,享年85岁,整个时尚界都为他的离世而感到震惊。
中国社科院表示,在中国的工业及相关领域中,农民工们提供了50%的劳动力。然而由于户籍规定,他们却无法享受到与城市居民同等的权利。
China’s trade surplus grew to Rmb496.2bn last month from Rmb382.1bn in December. Economists expected it to inch higher to Rmb389bn. In dollar terms, China’s trade surplus rose to $63.29bn from $60.09 in December and versus expectations of $60.6bn.
苹果公司首席执行官蒂姆库克

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

vt. 切成薄片,削
The programme focuses on the early careers of the children that are enrolled in the Abby Lee Dance Company in Pittsburgh, Pennsylvania.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

但经济学家总体上预计,一旦飓风造成的失真消失,前段时间的趋势就有望恢复并延续。接受《华尔街日报》最新月度调查的45位经济学家预计,到明年6月,失业率将降至7.8%,2013年年底将降至7.5%。部分经济学家说,就业增长可能会摆脱现在的缓慢速度而加快。信安环球投资有限公司(Principal Global Investors)经济学家鲍尔(Bob Baur)说,我觉得到时候企业将必须招人。[qh]
《少年收容所》(Short Term 12)是独立制片的小型影片之一,然而却会大大地影响观众。这部低成本电影片长仅96分钟,背景是一个针对问题青少年的收容设施。然而德斯汀?克里顿(Destin Cretton)的导演和布里?拉尔森(Brie Larson)的表演让这部电影跻身年度最佳影片之列。拉尔森几乎可以肯定无缘奥斯卡奖(今年的竞争异常激烈),但她对所扮演的女主角格蕾丝(Grace)的刻画极具水准,格蕾丝是一名20多岁的年轻保育员,她自己的生活远非平静无波。
喜剧类最佳男演员:杰佛里?塔博(Jeffrey Tambor),《透明家庭》(Transparent)

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

According to a 2014 survey it conducted, 86 per cent of respondents who finished the two years said they were taking action to end educational in-equality through their work and 65 per cent outside of their work.
我以前曾有过一款安卓手机(尽管2009年以来我一直用的是MacBook笔记本电脑,这种搭配挺诡异的,我知道)。自从今年夏天换了iPhone以后,我马上意识到了iPhone“提醒”的力量。每次有提醒事项时,iPhone就会振动起来,然后显示一个弹出窗口,你可以暂停它,或者把它标记为已完成。另外你还可以设置重复提醒,用来提醒你邮寄每个季度的税单、更新订阅、领薪水等容易忘记的事再好不过了。

Spotlight

Advertisements