Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The most popular surgical procedures include double eyelid surgery - which reduces excess skin in the upper eyelid to make the eyes appear bigger, lipoplasty - which uses high-frequency sound waves to eliminate fat - and nose jobs.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The pipelines were building in spite of poor performance for this year’s high-profile deal from Snap, the owner of Snapchat, in the US and investor concerns that a strengthening euro may curtail the earnings recovery in Europe.
白人焦虑推动了今年的西方政治动荡：英国令人震惊地投票决定退出欧盟，美国的唐纳德?J?特朗普(Donald J. Trump)出人意料地获得了共和党的总统提名，挪威、匈牙利、奥地利和希腊的右翼民族主义崛起。
Trends and targets in antiviral phototherapy
9.Use One Planner
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Among the major U.S. airlines, US Airways had the best holiday on-time performance, coming in fifth with 15.57 percent of its flights arriving late during Thanksgiving and Christmas. Meanwhile, American Airlines, with which US Airways plans to merge, was the fourth worst, with 19.7 percent of flights arriving late, according to FlightAware.
Novel biosensing methodologies for ultrasensitive detection of viruses
Net interest margins — the difference between interest paid on deposits and interest gained from loans — suffered as China lifted its remaining controls on the interest rates paid on deposits. The average margin declined by about 46 basis points to 2.54 per cent in 2015.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Man got to sit and wonder ‘why, why, why?’
In 55th place, University of Edinburgh Business School regains the rank it held two years ago. The school dropped down the tables last year after failing to make it into the Masters in Management ranking. The University of Bradford School of Management recorded its best progression, aided by the school’s first appearance in the ranking of the top 100 Executive MBAs.
ACE2 as a potential therapeutic target for pandemic COVID-19
The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.
Another love ballad for Bond, but if Nancy Sinatra's song from You Only Live Twice was playing at your orthodontist's office, it would be the sexiest orthodontist's office in town. There's a mysterious quality to the string section, and a playfulness to the declining notes. They combine to make something rather magical. From here on out all of the Bond songs on this list are bona fide classics.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
200911/90348.shtmlHere are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!
Feud: Bette and Joan
During the summers, Good Humor ice cream trucks visit the company's campuses every other Friday during lunchtime. In the fall, cider and doughnuts are served twice a month, mid-morning.
Form without content. Which is why devolving to such familiar forms seems like a safe bet, and why it really isn’t. It’s empty and disposable — which is in turn why the 1960s keep being identified as a “trend,” with the associated implication that at some point they will also be identified as “over.” Even though that “over” has yet to come.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Song “Family”(Tan Jing)
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Wang, the chairman of Dalian Wanda Group, took the top spot with a personal fortune of $32.1 billion, the report said, despite Ma seeing his wealth surge 41 percent from 2015.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
That Apple could launch a 2,000 yuan ($330) iPhone mini and be competitive with flagship products from Lenovo, Huawei, ZTE and Coolpad.
2. Do I have too much clutter? Drowning ourselves in too many material possessions can ultimately lead to stress. Get clear on what you absolutely need and what you can get rid of.
Influenza neuraminidase: A druggable target for natural products
May you have the best New Year ever.
Song “Embrace Happiness”(Kelly Chen)
1. Discipline them: Of course disciplining our children is a given in any home. But we need to ask ourselves if we are disciplining our children properly? Who
Heavy air pollution from Beijing, which saw its worst bout of smog in recent history in January, to Shanghai, where pollution levels went off the charts in December, certainly don't do much to help attract tourists.
Beijing Capital International Airport performed slightly better, with its punctuality rate reaching 60.7%.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
There's plenty more to figure out in the coming months, plenty more to speculate about, plenty more to enjoy. Here's wishing all of our readers a safe and enjoyable holiday season, and a happy new basketball year.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
adj. 浓缩的；扼要的 vt. 浓缩（condense
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
“Why do we keep getting so many record-warm years?” Dr. Schmidt asked in an interview. “It’s because the planet is warming. The basic issue is the long-term trend, and it is not going away.”
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
This was never more powerful than when he talked publicly for the first time about his sexuality.
Other engines cited among 2014’s best include turbodiesels in the BMW 5 Series luxury sedan and the compact Chevrolet Cruze, the horizontally opposed 2.7-liter six-cylinder in the Porsche Cayman two-seat sports coupe and the 1.8-liter turbo-four in the compact Volkswagen Jetta sedan.
Inhibition of SARS coronavirus helicase by bismuth complexes
Committee Chairman Thorbjoern Jagland praised the work of the three recipients, saying that "we cannot achieve lasting peace in the world unless women obtain the same opportunities as men."
“It suggests that people put more weight on what happened to themselves and less weight on other information that might be available,”Koudijs says. The more personally removed people are from an important event, the less it is to affect their appetite for risk.
10. Mail carrier
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A powerful earthquake struck off Japan's southern coast on May 30, prompting fears in China of a catastrophe similar to the tsunami and Fukushima nuclear power plant meltdown that followed the 2011 Japanese quake. In the end, no fatalities or major damage were reported.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
China's mass entrepreneurship and innovation initiative has a strong vitality.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
It plans to help at least 130,000 rural people cast off poverty and relocate 163,000 residents in 2017.
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Meanwhile the services PMI reading for the month was 51.2. It had been 52 in October. The manufacturing PMI, reported earlier this week, came in at 48.6 in November, versus expectations of 48.3. It had been 48.3 in October
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
According to the report, people living in first-tier cities such as Beijing, Shanghai, Guangzhou and Shenzhen suffer much higher economic pressure, while fourth-tier and smaller cities offer fewer job opportunities and connection plays an important role in every aspect of life there.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Shares in Hyundai and AmorePacific slid on Friday, down 4.4 per cent and 12.5 per cent respectively in late afternoon trading in Seoul.
We will promote the liberalization and facilitation of international trade and investment.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Faster growth should also dispel worries about another Fed bogeyman: deflation, or falling prices. "It's impossible to have deflation in an economy growing 3%-plus and adding the most jobs since the 1990s," Baumohl said.
When things do go wrong, Mr Cook takes swift and merciless action. In late 2012, after the premature launch of Apple’s flawed Maps app, he dismissed Scott Forstall, who led the creation of iOS and was a close ally of Jobs, and John Browett, the former Dixons chief who had led Apple retail for less than a year. The actions sent a message that Mr Cook will not tolerate underperformance or internal politics.
If successful, the funding would underline the rapid growth of the sector this year. In April, Lufax raised $500m at a $10bn valuation.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
On Aug 21, the country came to a pause as millions of Americans — even the president — put on eclipse glasses and stopped to take in the first eclipse to cross the United States since 1918. Its path across the United States was a scientific bonanza for astronomers who were able to more easily point advanced equipment at the sun.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
4) I often feel inhibited in social interactions 0 1 2 3 4
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Hurun estimates that there are now 594 US dollar billionaires in China and another 94 in Hong Kong, Taiwan and Macau, compared with 535 in the US.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
3. The root cause of eczema has finally been identified. Scientists have tracked down a series of proteins and molecular pathways that lead to this insufferable skin problem, revealing that the protein filaggrin isn't the sole culprit we thought it was.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Summly and Yahoo refused to comment on the deal’s terms.
Wang Chunfa, executive secretary of the China Association for Science and Technology, has expressed deep concern over the retraction, which came just days after he met in Beijing with Arnout Jacobs, the head of Springer Nature for Greater China.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
For those outside the scientific community, the response to the retraction has been mixed.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
*Guest Actor in a Drama Series: Hank Azaria, “Ray Donovan”
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The report ranks brands based on financial performance, its influence on customers, and its power to command a premium price or drive company sales.
A modular microarray imaging system for highly specific COVID-19 antibody testing
这间增加的厨房大约40英尺长(约12米)，风格与原建筑保持一致，内有复杂的天花板木制结构和几处由世纪工作室(Century Studios)设计的彩色玻璃板，该工作室是明尼阿波利斯市的一家公司，其玻璃确保来自弗兰克·劳埃德·赖特(Frank Lloyd Wright)曾指定的那家芝加哥制造商。厨房里的不锈钢电器包括一台五英尺宽（约1.5米）的炉灶和一台Sub-zero的冰箱。餐厅区经由10英尺高（约3米）的玻璃门通往屋后的一处露台。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The year’s most compelling makeup and hair designs have been almost characters themselves (and are certainly more dynamic than some of those who appear on-screen). But while physical features are obvious right away, they can also give shape and nuance to the performances of those who assume them. Sometimes, a big nose creates a window of understanding.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Stand: Costco CEO Craig Jelinek refused to open on Thanksgiving Day
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
这个领域的创新速度非常快。自从Fitbit于2008年成立以来，各家公司已经发布了五到六个完全不同的产品。三星（Samsung）则在九个月内发布了可穿戴设备Galaxy Gear的三到四个衍生产品。索尼（Sony）、Pebble、谷歌和Facebook的头戴式虚拟现实设备Oculus Rift也紧随其后。
World Health Organisation declared that the cluster of microcephaly cases and other neurological disorders were a public health emergency of international concern, it was a rallying cry for the international community to respond.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
8. Flats are allowed on the red carpet – or are they?
But when you think of fields where there just aren't enough skilled candidates to go around, one that probably doesn't come to mind is supply chain management: The complicated, behind-the-scenes work of getting goods from one place to another, on time and on budget.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Yet, the disparity in haircuts lasted for almost two years. In fact, the pessimism and risk-aversion of the Seppenwolde lenders reduced the overall availability of leverage in Amsterdam.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Meditate any time, but 15 minutes before you study, 15 minutes before class, 15 minutes before a test, and you'll be amazed at how well you can perform as a student.
节目31 京剧《迎来春色换人间》，于魁智 托马斯（孔子学院学员）
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
In month-on-month terms prices rose only 0.6 per cent nationwide, the first time growth fell below one percentage point in three months and well down from a peak of 2.1 per cent in September.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
8. Trang Islands, Thailand-The islands of Trang, a sleepy province in southeast Thailand, have remained under the radar. Wooden longtail boats can be rented to travel between the islands—and to see the endangered dugongs.
伊法斯夫拉腾以英国独立党(U.K. Independence Party)为例，它的官方平台力主脱欧，但是面向选民的宣传中又强调移民对经济与文化的影响，她说这是一种混合了务实与民粹的论调。
Length-scale dependence of protein hydration-shell density
China’s trade surplus grew to Rmb496.2bn last month from Rmb382.1bn in December. Economists expected it to inch higher to Rmb389bn. In dollar terms, China’s trade surplus rose to $63.29bn from $60.09 in December and versus expectations of $60.6bn.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The programme focuses on the early careers of the children that are enrolled in the Abby Lee Dance Company in Pittsburgh, Pennsylvania.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
但经济学家总体上预计，一旦飓风造成的失真消失，前段时间的趋势就有望恢复并延续。接受《华尔街日报》最新月度调查的45位经济学家预计，到明年6月，失业率将降至7.8%，2013年年底将降至7.5%。部分经济学家说，就业增长可能会摆脱现在的缓慢速度而加快。信安环球投资有限公司(Principal Global Investors)经济学家鲍尔(Bob Baur)说，我觉得到时候企业将必须招人。[qh]
《少年收容所》(Short Term 12)是独立制片的小型影片之一，然而却会大大地影响观众。这部低成本电影片长仅96分钟，背景是一个针对问题青少年的收容设施。然而德斯汀?克里顿(Destin Cretton)的导演和布里?拉尔森(Brie Larson)的表演让这部电影跻身年度最佳影片之列。拉尔森几乎可以肯定无缘奥斯卡奖（今年的竞争异常激烈），但她对所扮演的女主角格蕾丝(Grace)的刻画极具水准，格蕾丝是一名20多岁的年轻保育员，她自己的生活远非平静无波。
About this collection
According to a 2014 survey it conducted, 86 per cent of respondents who finished the two years said they were taking action to end educational in-equality through their work and 65 per cent outside of their work.